A 1-mg dose of inhaled albuterol produced a peak plasma concentration of 2 ng/mL
Totally, twelve metabolites of (R)-salbutamol were found and identified and all the metabolites could be found in urine, one metabolite in plasma and two metabolites
Subsequently, (S)-salbutamol predominates due to absorption and metabolism of the swallowed portion of the inhaled dose
; Suwandecha T
Salbutamol, a bronchodilator recommended for the treatment of respiratory diseases, is metabolized by cytochrome P450 (CYP) enzymes, which
involved in metabolism
After oral inhalation, 80—100% of a dose is excreted via the kidney, whilst 10% may be eliminated in faeces
This chapter describes the physical properties, synthesis, metabolism, absorption, excretion, and methods of analysis of salbutamol
3109/00498257309151506
Salbutamol can be administered orally, intravenously (IV), intramuscularly (IM), subcutaneously, or by inhalation
5 hour for nebulized delivery to 2 to 4 hours for delivery by a metered-dose inhaler (MDI)
Metabolic effects of salbutamol: comparison of aerosol and intravenous administration Br Med J
The fate of 3 H-salbutamol given orally, by aerosol and intravenously, has been investigated in asthmatic patients
Pre-systemic metabolism in the lung can be different from the liver metabolism because of the differences in cellular functions and the enzymatic activity of the airways and liver cells
The present results indicate that TB-β-CyD may be a useful carrier for orally administered water-soluble drugs, especially for drugs which are metabolized extensively in the gastrointestinal tract
Therefore, our findings may contribute to the in-depth understanding of metabolic regulation of budesonide and salbutamol in
A 36 year old woman with asthma since childhood, treated with inhaled fluticasone + salmeterol and inhaled salbutamol, had a history of alcoholism, frequent hospitalizations with acute severe asthma, poor adherence to treatment, and misuse of salbutamol
[] Salbutamol has potent smooth muscle relaxant properties and is in widespread use as a bronchodilator in the