This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and
Results: 160 patients underwent P2Y12 platelet function tests
VerifyNow P2Y12 assay is used to measure the effect of P2Y12 ADP-receptor inhibitors clopidogrel and prasugrel
The objectives of this review are to discuss the pharmacological limitations of the P2Y12 inhibitor clopidogrel, and describe the novel alternative P2Y12 inhibitors
Platelet inhibition ranged from 0% to 89%
Clopidogrel is an irreversible inhibitor of the platelet P2Y12 adenosine diphosphate receptor
Cytochrome P450 2C19 (CYP2C19) is a drug-metabolizing enzyme involved in the metabolism of several clinically important drugs including the platelet aggregation
We report the use of a new P2Y12 point-of-care assay (VerifyNow; Accumetrics, San Diego, CA) to determine the magnitude of platelet inhibition in trauma patients using The Plavix Response test joins the existing Aspirin Resistance assay, also performed on the VerifyNow system
114 – 116 The principle on which it is based is platelet activation due to Platelet antibodies may be directed to a number of antigenic “targets” carried on platelet cytoplasmic membranes
Values of 550-700 ARU are seen in patients not on aspirin therapy or where therapy is not effectively inhibiting platelet function
10 ADP is used to maximally activate the platelets by binding to the P2Y1 and P2Y12 platelet receptors
Do Not Overfill
Platelet inhibition by Plavix is irreversible and will last for the life of the platelet
TEG platelet mapping can detect platelet inhibition by clopidogrel and aspirin in surgical patients
It is a global hemostasis test that is additionally able to monitor antiplatelet inhibition of arachidonic acid (AA) and adenosine diphosphate (ADP Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by thrombelastography platelet mapping
Simple test; quick to use; many clinical areas already use thromboelastography for other indications: Small sample volume; high accuracy; good correlation with light transmission aggregometry; can be used for multiple applications It is also suggested that testing for the magnitude of platelet inhibition in patients on
Patients with HCT<20% or PLT<50 K/uL cannot be tested with the VerifyNow Assay
Proton pump inhibitors are medicines that decrease stomach acid to lower the risk of getting an ulcer
VerifyNow PRUTest* Measures the level of platelet P2Y12-receptor blockade to help identify patient response to antiplatelet therapy, including clopidogrel (Plavix), prasugrel (Effient) and ticagrelor (Brilinta)