Clonidine is an antihypertensive drug that lowers blood pressure and heart rate by relaxing the arteries and increasing the blood supply to the heart; it has the following FDA-approved indications: Clonidine is a commonly prescribed biochemical derivative of imidazoline with a variety of clinical uses
It works in the brain to change some of the nerve impulses
Damage to these organs may cause heart disease, a heart attack Clonidine is an antihypertensive drug that lowers blood pressure and heart rate by relaxing the arteries and increasing the blood supply to the heart; it has the following FDA-approved indications: Byerley EM, Mohamed MW, Grindeland CJ, Muzzy Williamson JD
No other drugs were allowed
Your doctor may adjust your dose as needed
Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
1 mg; 0
Uses Warnings Before taking Dosage Clonidine is a type of medicine called a vasodilator
2 mg clonidine daily for one week
Opioid withdrawal can be precipitated with administration of antagonist (e
Symptoms are usually uncomfortable but not life-threatening and manifest with agitation and restlessness but does not cause altered mental status
Clonidine (known by the trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a depressant substance of the imidazoline class
This page was last edited 16:57, 3 March 2021 by
2013 Nov 1;88(9):589-595
Dosing
5mg-1mg IV over 5min (repeat dosing up to 2mg in first hour) [3] Onset of action: 5-10min
Not an opioid, but often combined with opioids and increases the risk of overdose and death
Hypotension
External - arises from blockage and infection of Zeis (sebaceous) or Moll (sweat) glands; Internal - arises from blockage and infection of meibomian glands Clonidine is used therapeutically for hypertension, opioid abuse, PTSD, and tobacco withdrawal; criminally, it has been used for drug-facilitated sexual assault Clinical Features Note that initial presentation may stem from non-specific peripheral alpha1 agonism, and produce hypertension and reflex tachycardia - will transition to bradycardia DTRs
look for QT prolongation, QRS prolongation, etc) Consider CBC, BMP, urinalysis (with ẞ-HCG if appropriate), urine toxicology screen, serum alcohol concentration, VBG
1mg/kg IV (max 2mg) Cyanide: Hydroxocobalamin OR Cyanokit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) Dabigatran: Idarucizumab 5mg IV Digoxin: Dig Immune Fab: Ethylene glycol: Fomepizole
Type: Anticholinergic Routes of Administration: IV/IM/IO/SC, endotracheal, nebulized, PO, topical/ophthalmic; Common Trade Names: Atropine, Atreza WikEM, The Global Emergency Medicine Wiki, is the world's largest and most popular emergency medicine open-access reference resource
AV node blocker: beta-blocker, verapamil or diltiazem - typically adherent with medication but an overdose
É usada principalmente para combater a resposta do sistema nervoso central à abstinência de opiáceos, isto é, taquicardia e hipertensão nos primeiros dias de abstinência
buprenorphine) [1] or as a result of cessation of use
IV or IM
Usually elevated; drain CSF until pressure is <20 or 50% of opening presure
Reduced CNS sympathetic flow, decreasing SVR, HR, BP; no renal blood flow changes; tolerance/tachyphylaxis develop quickly
5-2mg IV over 5min
Lofexidine, sold under the brand name Lucemyra among others, is a medication historically used to treat high blood pressure; today, it is more commonly used to help with the physical symptoms of opioid withdrawal
Bowel Sounds
Not an opioid, but often combined with opioids and increases the risk of overdose and death
et al
[1] [2] Signs and symptoms of withdrawal can include drug ↑ James PA, et al
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Initiate low dose levothyroxine at 25mcg daily only if patient has signs and symptoms of hypothyroidism
An injury or lesion in either pathway may result in changes in pupil size
Withdrawal from clonidine presents with tachycardia, hypertension
Clonidine is an antihypertensive drug that lowers blood pressure and heart rate by relaxing the arteries and increasing the blood supply to the heart; it has the following FDA-approved indications:
Other reported clinical uses include treatment of opiate and alcohol withdrawal [ 1]
Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents
Topics: Background: Clonidine is a recommended therapy for the treatment of attention deficit hyperactive disorder in children
A central alpha 2 agonist that does suppress the sympathetic hyperactivity that results during acute withdrawal; Dosing: 0
Clonidine is a selective α2 agonist that has potent antihypertensive effects
Generally for outpatient treatment of mild cases and as a taper
Clonidine is used therapeutically for hypertension, opioid abuse, PTSD, and tobacco withdrawal; criminally, it has been used for drug-facilitated sexual assault Clinical Features Note that initial presentation may stem from non-specific peripheral alpha1 agonism, and produce hypertension and reflex tachycardia - will transition to bradycardia General
CSF Studies
Intentional abuse (generally adolescents, young adults) Occupational exposure - dermal, inhalation
Localizes to epigastric area, around waist, RUQ, or occasionally LUQ
Always have atropine at the bedside for bradycardia or cholinergic excess
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Hyperkalemia
No histamine release
Dysphonia, stridor, respiratory distress
Nl / ↓
Alcohol withdrawal
5 ml of 10mg/ml phenylephrine, and dilute in 9
Clonidine is an antihypertensive medication that acts on alpha-adrenergic and imidazoline receptor agonists
1mg/kg IV (max 2mg) Cyanide: Hydroxocobalamin OR Cyanokit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) Dabigatran: Idarucizumab 5mg IV Digoxin: Dig Immune Fab: Ethylene glycol: Fomepizole
Other items on the differential include dissection, AMI, hypoglycemia or other metabolic derangement such as hepatic/uremic encephalopathy, medication side effect, or post-ictal Todd’s paralysis
Side effects are usually mild and include sedation, fatigue, bradycardia, dry mouth, headaches, dizziness, postural hypotension, male impotence and gastrointestinal upset
An injury or lesion in either pathway may result in changes in pupil size